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KMID : 1149220050130020059
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Korean Journal of Oriental Medical Prescription
2005 Volume.13 No. 2 p.59 ~ p.69
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Effect of Samyoyongantang on Contact Hypersensitivity induced by Repeat Elicitation of DNCB
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Byun Sung-Hee
Lee Byung-Wook
Kim Sang-Chan
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Abstract
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Samyoyongantang (SMY), a herbal medicine, has been used as cure for gangrene. To evaluate anti-inflammatory effect of samyoyongantang, we treated samyoyongantang extract in animal model system induced contact hypersensitivity. Contact hypersensitivity, a local inflammatory response of the skin, was induced by 1% DNCB on the right ear of BALB/c mouse. Samyoyongantang was prepared as water extract and administrated everyday for 2 weeks per oral. A right ear of mouse was potently swelled by 1% of DNCB treatm ent, but a mouse ear thickness was significantly reduced by samyoyongantang after 2 we eks treatment. Samyoyongantang reduced IgG in serum obtained from blood of 1 % DNCB-treated mouse. IgE in serum was not changed by samyoyongantang treatment. From these results, anti-inflammatory effect of samyoyongantang, especially reduction of ear swell ing, might be partly due to reduction of IgG in serum.
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KEYWORD
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Samyoyongantang, Contact hypersensitivity, DNCB
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